Skip to Main Navigation Skip to Content
Collaborative global initiatives in science

Main Content

Symposium 2013

The Macrae Foundation’s XV International Symposium on Respiratory Viral Infections was held 14-17 March 2013 in Rotterdam, The Netherlands with the following Chairs, Scientific Advisory Board and Program:

Chairs:

Menno de Jong Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Albert Osterhaus Professor of Virology, Erasmus MC, Rotterdam, The Netherlands

Scientific Advisory Board:

W. Abdullah Brooks Director Kamalapur Field Site, Head Infectious Diseases Unit (ICDDR,B), Johns Hopkins Bloomburg School of Public Health, Dhaka, Bangladesh and Baltimore, Maryland, USA (confirmed)
Nancy Cox Director, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA (confirmed)
Frederick Hayden Professor of Medicine and Stuart S. Richardson Professor of Clinical Virology, University of Virginia School of Medicine, Charlottesville, Virginia, USA (confirmed)
Sebastian Johnston National Heart & Lung Institute, Imperial College, London, United Kingdom (confirmed)
Yoshihiro Kawaoka University of Tokyo, Tokyo, Japan; University of Wisconsin, Madison Wisconsin, USA (confirmed)
Arnold Monto Thomas Francis Jr Professor of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA (confirmed)
Malik Peiris School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong SAR, China (confirmed)
Paul Tambyah Infectious Diseases, University of Singapore Hospital, Singapore (confirmed)

 

Thursday, March 14, 2013 – Opening Keynote

17.00 – 17.05 Welcome – Cathryn Macrae
17.05 – 17.10 Introduction of Keynote Address – Albert Osterhaus
17.10 – 17.55 Keynote Address
The New Human Coronavirus (HCoV-EMC): Identification and Pathogenesis – Ali Mohamed Zaki, Medical Microbiology and Immunology,Faculty of Medicine, Ain Shams University, Cairo, Egypt (confirmed) and Bart Haagmans, Erasmus MC, Rotterdam, The Netherlands (confirmed)
18.00 – 19.30 Welcome Reception

Friday, March 15, 2013 – Day 1

Session I Influenza – Chairs: Nancy Cox, Director, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA and Young Scientist (TBD)
09.00 – 09.30 Transmissibility of Avian (H5N1) Influenza Virus in Mammals: Where we Stand I – Yoshi Kawaoka, University of Tokyo, Tokyo, Japan and University of Wisconsin, Madison, Wisconsin, United States (confirmed)
09.30 – 10.00 Transmissibility of Avian (H5N1) Influenza Virus in Mammals: Where we Stand II – Ron Fouchier, Erasmus MC, Rotterdam, The Netherlands (confirmed)
10.00 – 10.30 Porcine Influenza Viruses In Human: What’s New – Nancy Cox, Centers for Disease Control and Prevention, Atlanta, Georgia, USA (confirmed)
10.30 – 10.50 Oral Presentation – Young Investigator Award Recipient
H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant – Erhard van der Vries, Erasmus Medical Center, Rotterdam, The Netherlands
10.50 – 11.10 Oral Presentation
Ferreting out influenza H5N1 quasispecies evolution during human infection by whole genome deep sequencing of clinical specimens from infected patients Matthijs R.A. Welkers, Dept. of Medical Microbiology, Academic Medical Centre, Amsterdam, The Netherlands
11.10 – 11.40 Coffee Break
11.40 – 12.00 Oral Presentation
Post-pandemic Review of Anti-Influenza Drug Effectiveness (PRIDE Study): An Individual Patient Data (IPD) Meta-analysis Investigating the Impact of Antivial use on Patient Outcomes during the 2009-10 Influenza A(H1N1) Pandemic – Puja Myles, University of Nottingham, United Kingdom
12.00 – 12.20 Oral Presentation
Monitoring the Receptor Binding Properties of new Pandemic H1N1 Viruses: Selection of Optimal Sialic Acid Binding Properties – Erik de Vries, Utrecht University, The Netherlands
Session II Clinical Intervention – Chairs: Menno de Jong, Academic Medical Center, University of Amsterdam, The Netherlands and Ross P. Walton, Imperial College, St. Mary’s Hospital, London, UK
12.20 – 12.50 Development of Monoclonal Antibodies – Tim Beaumont, AIMM Therapeutics, Amsterdam, The Netherlands (confirmed)
12.50 – 13.20 Literature Review: Antivirals – Frederick Hayden, Professor of Medicine and Stuart S. Richardson Professor of Clinical Virology, University of Virginia School of Medicine, Charlottesville, Virginia, USA (confirmed)
13.20 – 15.00 Lunch Break
15.00 – 15.45 Keynote Address
The Sense and Nonsense of Diagnostics – Christian Drosten, Bernhard-Nocht-Istitut, Hamburg, Germany (confirmed)
15.45 – 16.05 Oral Presentation
Lethal Mutagenesis Induced by T=705 (Favipiravir) in Influenza A (H1N1) Viruses – Elena A. Govorkova, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA
16.05 – 16.25 Oral Presentation
Symptom resolution is significantly faster in oseltamivir-treated than untreated patients in Year 4 of the Influenza Resistance Information Study (IRIS) – Charles Boucher, Erasmus Medical Center, Rotterdam, The Netherlands
16.25 – 16.45 Oral Presentation
Novel Inhibitors of Rhinovirus Replication – Frank van Kuppeveld, Utrecht University, The Netherlands
16.45 – 17.00 Short Coffee Break – 15 minutes with continous service
17.00 – 17.45 Poster review – Albert Osterhaus, Professor of Virology, Erasmus MC, Rotterdam, The Netherlands (confirmed)
17.45 – 19.45 Poster Session –
17.45 – 18.15 Science and Politics: Where do we go? – Derek Smith, University of Cambridge, United Kingdom (confirmed)
18.15 – 19.45 Reception and Posters

 

Saturday, March 16, 2013 – Day 2

Session III One Health – Chairs: Albert Osterhaus, Professor of Virology, Erasmus MC, Rotterdam, The Netherlands and Leslie Reperant, Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA (confirmed)
08.30 – 09.00 The Animal-Human Interface: When, Where and How – Albert Osterhaus, Professor of Virology, Erasmus MC, Rotterdam, The Netherlands (confirmed)
09.00 – 09.20 Oral Presentation
Modeling the Nipah Virus Transmission Cycle – Vincent J. Munster, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, Montana, USA (confirmed)
09.20 – 09.40 Oral Presentation
Influenza Virus Tropism for the Respiratory Tract and Viral Fitness: Cell Type and Location Matter – Leslie Reperant, Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA
09.40 – 10.00 Oral Presentation
Emergence of the Virulence-associated PB2-E627K Substitution in a Fatal Human Case of Highly Pathogenic Avian Influenza Virus A(H7N7) Infection, Determined by Illumina Ultradeep Sequencing – Marcel Jonges, Department of Virology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven; Department of Virology, ErasmusMC, Rotterdam, The Netherlands
Session IV Latebreaker Oral Abstracts – Chairs: Derek Smith, Cambridge University, United Kingdom and Young Scientist (TBD)
10.00 – 10.20 Oral Presentation
Clinical Effectiveness of the Neuraminidase Inhibitors, Oseltamivir, Zanamivir, Peramivir, and Laninamivir and Viral Shedding – Norio Sugaya, Department of Pediatrics, Keiyu Hospital, Yokohama, Japan
10.20 – 10.40 Oral Presentation
Years of Life Lost in the First Wave of 2009 Pandemic (H1N1) in Hong Kong – Ying Zhou, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China
10.40 – 11.10 Coffee Break
11.10 – 11.30 Oral Presentation
Causal Relationship between Respiratory Syncytial Virus Infection and Recurrent Wheeze during the First Year of Life – Louis Bont, University Medical Center, Pediatric Immunology and Infectious Diseases, Utrecht, The Netherlands
11.30 – 11.50 Oral Presentation
Zoonotic Potential of an H1N2 Influenza Swine Virus in Ferrets: Continuing Threat of Triple-reassortant Swine Viruses? – Young-Ki Choi, College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju, 361-763, Rep. of Korea
Session V Pathogenesis of Respiratory Virus Infections I – Chairs: Malik Peiris, School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong SAR, China and Young Scientist (TBD)
11.50 – 12.20 Host Genetics of Respiratory Virus Disease – Paul Kellam, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom (confirmed)
12.20 – 12.40 Oral Presentation
The Use of Human Ex-vivo Tissues to Evaluate the Pathogenesis and Tropism of a Novel Coronavirus – John M. Nicholls, The University of Hong Kong, Pok Fu Lam, Hong Kong
12.40 – 13.00 Oral Presentation
Excessive Production and Extreme RNA editing of Defective Interfering Particles is Associated with IFN Induction by HMPV – Bernadette G. van den Hoogen, Erasmus MC, Rotterdam, The Netherlands
13.00 – 13.20 Oral Presentation
Systems Biology of Respiratory Virus Infections: Are Host-Response Networks more complicated than Social Networks? – Michael G. Katze, University of Washington, Seattle, Washington, USA
13.20 – 14.50 Lunch Break
Session VI Vaccines – chairs: Arnold Monto, Thomas Francis Jr Professor of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States and Young Scientist (TBD)
14.50 – 15.20 Vaccine Needs from a Global Perspective and Vaccination in Pregnancy – W. Abdullah Brooks, Director Kamalapur Field Site, Head Infectious Diseases Unit (ICDDR,B), Johns Hopkins Bloomburg School of Public Health, Dhaka, Bangladesh and Baltimore, Maryland, USA
15.20 – 15.40 Oral Presentation
MF59®-Adjuvanted Influenza Vaccine: an Update – Theodore F. Tsai, Novartis Vaccines and Diagnostics, Cambridge, Massachusetts, USA
15.40 – 16.00 Oral Presentation
MVA-based Influenza Vaccine Development: from Bench to Bedside – Joost Kreijtz, Erasmus MC, Rotterdam, The Netherlands
16.00 – 16.20 Oral Presentation
Safety, Immunogenicity and Efficacy, of a Sf9 Insect Cell-derived Respiratory Syncytial Virus Fusion Protein Nanoparticle Vaccine in Cotton Rats and Comparative Immunogenicity in Humans – Gregory M. Glenn, Novavax, Rockville, MD, USA
16.20 – 16.50 Coffee Break
Session VII Respiratory Viruses at the Extremes of Age – Chairs: Terho Heikkinen, Turku University Hospital, Turku, Finland and Pieter L.A. Fraaij, Erasmus MC, Rotterdam, The Netherland
16.50 – 17.20 Respiratory Viruses in Pediatrics – Terho Heikkinen, Turku University Hospital, Turku, Finland (confirmed)
17.20 – 17.50 Respiratory Viruses in the Elderly – Janet McElhaney, Advanced Medical Research Institute of Canada, Sudbury, Ontario, Canada (confirmed)
17.50 – 18.10 Oral Presentation
Prevalence of Rhinovirus in the first years of life in an Unselected Birth Cohort – Katja C. Wolthers, Academic Medical Center, Amsterdam, The Netherlands
18.10 – 18.50 Oral Abstracts X2

 

Sunday, March 17, 2013 – Day 3

Session VIII Pathogenesis of Respiratory Virus Infections II – Chairs: Paul Kellam, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom and Ken Baillie, Roslin Institute, University of Edinburg, Scotland, United Kingdom (confirmed)
08.00 – 08.30 Talk Title TBD: TBD
08.30 – 09.00 Literature Review: Pathogenesis of SARI – Thijs Kuiken, Erasmus MC, Rotterdam, The Netherlands (confirmed)
09.00 – 09.20 Oral Presentation
Severe Acute Respiratory Syndrome Envelope Protein Deletion Reduced the Virus Induced Proinflammatory Response and led to a Promising Vaccine Candidate – Luis Enjuanes, National Center of Biotechnology (CNB-CSIC), Madrid, Spain
09.20 – 09.40 Oral Presentation
Host Interaction during Respiratory Syncytial Virus Infection – Do Lien Anh Ha, Centre for ropical Medicine, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
09.40 – 10.00 Oral Presentation
Molecular Epidemiology of Adenovirus Type 21 Respiratory Infections among Unvaccinated US Military Recruits in Basic Training (1996-2011) – Adriana Kajon, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
10.00 – 10.30 Coffee Break
10.30 – 10.50 Oral Presentation
Full genome deep sequencing and phylogenetic analysis of a novel human betacoronavirus provide insights into the natural diversity and evolutionary origin of the virus – Matthew Cotten, Welcome Trust Sanger Institute, Cambridge, United Kingdom
10.50 – 11.10 Oral Abstract
Session IX Viro-bacterial interface – Chairs: Keith Klugman, Emory University, Atlanta, Georgia, United States and Debbie Bogaert, Utrecht University, The Netherland (confirmed)
11.10 – 11.40 Influenza Facilitation of Pneumococcal Transmission and Lethality – Keith Klugman, Emory University, Atlanta, Georgia, United States
11.40 – 12.00 Oral Presentation
Newly Identified Sequences of Influenza A Protein PB1-F2 that Predict Severity of Viral and Secondary Bacterial Infections – Irina Alymova, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA
12.00 – 12.20 Oral Presentation
Exploring Microbiome Changes during Experimental Human Rhinovirus Infection – JJ Hofstra, Dept of Medical Microbioly, Academic Medical Centre, Amsterdam, The Netherlands
12.20 – 12.40 Oral Abstract
12.40 – 13.00 Conclusions and Closing Remarks – Menno de Jong, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands and Albert Osterhaus, Professor of Virology, Erasmus MC, Rotterdam, The Netherlands (confirmed)