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XIV International Symposium on Respiratory Viral Infections

The Macrae Foundation’s XIV International Symposium on Respiratory Viral Infections was held 23-26 March 2012 in Istanbul, Turkey with the following Chairs, Scientific Advisory Board and Program:

Chairs:

Selim Badur Professor, Department of Microbiology, Division of Virology and Immunology, Istanbul University Medical School, Istanbul, Turkey
Nancy Cox Director, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Frederick Hayden Professor of Medicine and Stuart S. Richardson Professor of Clinical Virology, University of Virginia School of Medicine, Charlottesville, Virginia, USA; Influenza Research Coordinator, The Wellcome Trust, London, United Kingdom
Arnold Monto Thomas Francis Jr Professor of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA
Albert Osterhaus Professor of Virology, Erasmus MC, Rotterdam, The Netherlands

 

Scientific Advisory Board:

Rick Bright Biomedical Advance Research and Development Authority, Washington, DC, USA
Meral Akcay Ciblak Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Menno de Jong Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
John DeVincenzo University of Tennessee, Memphis, Tennessee, USA
Sebastian Johnston National Heart & Lung Institute, Imperial College, London, United Kingdom
Yoshihiro Kawaoka University of Tokyo, Tokyo, Japan; University of Wisconsin, Madison Wisconsin, USA
Malik Peiris Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
Fernando Polack Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Kevin Russell Armed Forces Health Surveillance Center, Silver Springs, Maryland, USA
Paul Tambyah Infectious Diseases, University of Singapore Hospital, Singapore

 

Program:

Day One — Friday, 23 March 2012

07.00 Registration Desk Opens, Foyer of the Grand Ballroom
09.00 – 09.10 Welcome – Cathryn Macrae, The Macrae Group LLC, and The Macrae Foundatiom
09.10 – 09.40 Keynote Address – Risk Assessment of New Emerging Novel Respiratory Viruses…. – Nancy Cox, Director, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

 

Session I Minisymposium: Animal/Human Interface – Chair: Albert Osterhaus, Professor of Virology, Erasmus MC, Rotterdam, The Netherlands
09.40 – 10.05 The Role of Birds in Pandemic Influenza – Giovanni Cattoli, Istituto Zooprofilattico Sperimentale delle Venezie, Padova, Italy
10.05 – 10.30 The Role of Swine Influenza – Richard Webby, Infectious Diseases, St Jude Children’s Research Hospital, Memphis, Tennessee, USA
10.30 – 10.45 Oral Presentation
Rates and Patterns of Genomic Reassortment of Influenza Viruses in North American Swine – Martha Nelson, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA
10.45 – 11.00 Oral Presentation – Young Investigator Award Recipient Sponsored by The Macrae Group LLC and Wellcome Trust
Cross-species Transmission of Pandemic Influenza (pH1N1) Virus in Backyard Pig Farms in Semirural Communities in Tumbes, Peru – Yeny Tinoco, US Naval Medical Research Unit – Six, Lima, Perú
11.00 – 11.30 Coffee Break, Foyer of the Grand Ballroom
11.30 – 11.45 Oral Presentation
Study of Avian Influenza infection among vaccinated and non vaccinated bird flocks in Egypt, 2007–2009 – Eman Abd Elkreem, FETP Coordinator, MOHP, Egyptian Board of Applied EpidemiologyTrainer, Cairo, Egypt

 

Session II Virology/Diagnostics – Chair: Malik Peiris, Department of Microbiology, University of Hong Kong, Hong Kong SAR, China
11.45 – 12.10 Multi- Respiratory Diagnostic Platform – Richard L. Hodinka, Clinical Virology Laboratory, Children’s Hospital of Philadelphia, Pennsylvania, USA
12.10 – 12.35 Paramyxovirus Virus: A Never-Ending Story – Albert Osterhaus, Professor of Virology, Erasmus MC, Rotterdam, The Netherlands
12.35 – 13.00 Novel Diagnostic Technologies – David Murdoch, University of Otago, Christchurch, New Zealand
13.00 – 15.00 Lunch Program
Viroclinics Satellite on the Pathogenesis and Combat of Influenza
A Satellite Symposium with Box Luncheon
Sponsored by Viroclinics Biosciences B.V.
Chair: Albert D.M.E. Osterhaus, Ph.D., Erasmus MC, Rotterdam, The Netherlands
Influenza Pandemic Preparedness: Where do we Stand? – Arnold Monto, Thomas Francis Jr Professor of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA
The Pathogenesis of Avian and Human Influenza – Yoshihiro Kawaoka, University of Tokyo, Tokyo, Japan; University of Wisconsin, Madison Wisconsin, USA
15.00 – 15.25 Infectious Disease Identification by Mass Spectrometry: A 21st Century National Diagnostics Strategy – David Ecker, Ibis Biosciences,an Abbott Company, Carlsbad, California, USA
15.25 – 15.40 Oral Presentation – Young Investigator Award Recipient Sponsored by The Macrae Group LLC
Characterization of the Fitness Impairments Induced by the H275Y Oseltamivir-resistance Mutation in the Influenza A/Brisbane/59/2007 and 2009 Pandemic H1N1 Backgrounds – Catherine Beauchemin, Ryerson University, Toronto, Canada
15.40 – 15.55 Oral Presentation
The Burden and Viral Etiologies of Severe Respiratory Illness in Rural Western Kenya, 2009 – 2011 – Rachel A. Ochola, KEMRI/CDC-Kenya, Kisumu, Kenya
15.55 – 16.10 Oral Presentation – Young Investigator Award Recipient Sponsored by The Macrae Group LLC and The Wellcome Trust
Detection of Polymorphisms at Residue 222 of the Pandemic Influenza A/H1N1 Hemagglutinin at Quasi-species Level: Association with Severe Cases – Paola Cristina Resende, Laboratory of Respiratory Viruses and Measles, Oswaldo Cruz Institute, Rio de Janeiro, Brasil
16.10 – 16.25 Oral Presentation
Pan-Pathogen Diagnostics – Insights from Clinical Validation Trials – Christopher Wong, Genome Institute of Singapore, Republic of Singapore

 

Session III Pathogenesis – Chair: Yoshihiro Kawaoka, University of Wisconsin, Madison Wisconsin, USA; University of Tokyo, Tokyo, Japan
16.25 – 16.45 Literature Review – Pre-Clinical SARS and Influenza – Malik Peiris, Department of Microbiology, University of Hong Kong, Hong Kong SAR, China
16.45 – 17.05 Literature Review – Pre-Clinical Rhinovirus and other Respiratory Viruses – TBA
17.05 – 17.30 Measles Immune Suppression: Lessons from the Macaque Model– Rik De Swart, Erasmus MC, Department of Virology, Rotterdam, The Netherlands
17.30 – 18.30 Welcome Reception

 

Day Two — Saturday 24 March 2012

Session III Pathogenesis – Chair: Yoshihiro Kawaoka, University of Wisconsin, Madison Wisconsin, USA; University of Tokyo, Tokyo, Japan (continued)
09.00 – 09.25 New Insights from Studies on Influenza – Yoshihiro Kawaoka, University of Tokyo, Tokyo, Japan; University of Wisconsin, Madison, Wisconsin, USA
09.25 – 09.50 Immunopathogenesis Implications for RSV – Fernando Polack, Division of Infectious Disease, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
09.50 – 10.15 Surprise H5N1 – Sander Herfst, Department of Virology, Erasmus MC, Rotterdam, The Netherlands
10.15 – 10.30 Oral Presentation
The PB1-F2 Protein Proapoptotic Sequence Contributes to Influenza A Virus Pathogenicity and Predisposition to Secondary Bacterial Infection – Irina V. Alymova, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA
10.30 – 10.45 Oral Presentation
The Influence of Smoking on Pulmonary Influenza Infection – an Ex vivo Study
John M. Nicholls, The University of Hong Kong, Pok Fu Lam, Hong Kong
10.45 – 11.00 Oral Presentation
Deficient Antiviral Responses to Influenza in Primary Bronchial Epithelial Cells of Chronic Obstructive Pulmonary Disease – Peter AB Wark, Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcstle, New South Wales, Australia
11.00 – 11.30 Coffee Break
11.30 – 11.45 Oral Presentation
Role of Toll-like Receptors in Naturally Occurring Influenza – Nelson Lee, Division of Infectious Diseases, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR
11.45 – 12.00 Oral Presentation
Viral Quasispecies Evolution of 2009 pH1N1 Influenza Virus during Serial Passaging in Differentiated Normal Human Airway Epithelial Cells – Matthijs R.A. Welkers, Department of Medical Microbiology, Academic Medical Centre, University of Amsterdam, The Netherlands

 

Session IV Epidemiology/Impact – Chair: Arnold Monto, Thomas Francis Jr Professor of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA
12.00 – 12.45 Special Invited Lecture: Lessons Learned from H1N1 Pandemic – Sylvie Briand, Influenza, Respiratory Diseases, Hepatitis, PIP framework (IRD/PED) Health Security and Environment (HSE), World Health Organization, Geneva, Switzerland
12.45 – 14.45 Lunch Program
PLEX-ID: At the Convergence of Broad Diagnosis and Surveillance
A Satellite Symposium with Box Luncheon
Sponsored by Ibis Biosciences, An Abbott Company
Technology Overview – Dr.David Ecker, Ibis Biosciences, Carlsbad, CA, USA
Molecular Testing for Respiratory Viruses using Mass Spectrometry
– Prof. Jacques Izopet, INSERM, Toulouse, FranceThe Case for Broad Respiratory Viral Testing – Prof. Dr. Oubaas Pretorius, PathCare, Cape Town, South Africa
14.45 – 15.10 Burden of Disease of Respiratory Viral Infections, a Geographical Prospective – W. Abdullah Brooks, Director Kamalapur Field Site, Head Infectious Diseases Unit (ICDDR,B), Johns Hopkins Bloomburg School of Public Health, Dhaka, Bangladesh and Baltimore, Maryland, USA
15.10 – 15.35 Estimating the Global Impact of Influenza – Marc-Alain Widdowson, Division of Viral Disease, Center for Disease Control, Atlanta, Georgia, USA
15.35 – 16.00 Importance of Respiratory Viral Diseases in Turkey – Meral Akçay Ciblak, Istanbul University, Istanbul Faculty of Medicine, Department of Microbiology and Clinical Microbiology, Virology and Fundamental Immunology Unit, National Influenza Reference Laboratory, Capa-Istanbul, Turkey
16.00 – 16.25 Burden of RSV in the Elderly – Ann Falsey, University of Rochester, Rochester, New York, USA
16.25 – 16.40 Oral Presentation
The Role of Respiratory Viruses in Lower Respiratory Tract Infections in Primary Care – Frank E. J. Coenjaerts, University Medical Center Utrecht, The Netherlands
16.40 – 16.55 Oral Presentation
A Large Epidemic of Enterovirus 71 Associated Hand, Foot and Mouth Disease in Southern Vietnam, 2011 – H. Rogier van Doorn, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
16.55 – 17.25 Poster Review – Albert Osterhaus, Erasmus MC, Rotterdam, The Netherlands
17:25 – 18.25 Poster Session Reception

 

Day Three — Sunday, 25 March 2012

Session IV Epidemiology/Impact – Chair: Arnold Monto, Thomas Francis Jr Professor of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA (continued)
08.30 – 08.45 Oral Presentation
Molecular Epidemiology of Adenovirus 4 and 7 Infections of Military Recruits in Training during the 15 Years with no Vaccination Program (1997-2011) – Adriana Kajon, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
08.45 – 09.00 Oral Presentation
A Retrospective, Observational Study on Incidence, Influenza-Associated Complications, and Treatment Patterns of Influenza in the United States: 2006–2010 Influenza Seasons – Philip Spagnuolo, Genentech, Inc., South San Francisco, California, USA
09.00 – 09.15 Oral Presentation
Spatial Epidemiology of Respiratory Syncytial Virus (RSV) in the USA – Cécile Viboud, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA
09.15 – 09.30 Oral Presentation
Individual Variability in Patterns of Viral Shedding in Influenza A Virus Infections – Lincoln L. Lau, School of Public Health, The University of Hong Kong, Hong Kong
09.30 – 09.45 Oral Presentation
Latitudinal Gradients in the Timing and Mortality Burden of the 2009 H1N1 Influenza Pandemic in Brazil – Wladimir J. Alonso, Division of Internataional Epidemiology & Population Studies, Fogarty International Center, National Institutes of Health-USA, Brazil

 

Session V Clinical – Frederick Hayden, Professor of Medicine and Stuart S. Richardson Professor of Clinical Virology, University of Virginia School of Medicine, Charlottesville, Virginia, USA; Influenza Research Coordinator, The Wellcome Trust, London, United Kingdom
09.45 – 10.05 Literature Review: Clinical Papers Adults + discussion– Frederick Hayden, Professor of Medicine and Stuart S. Richardson Professor of Clinical Virology, University of Virginia School of Medicine, Charlottesville, Virginia, USA; Influenza Research Coordinator, The Wellcome Trust, London, United Kingdom
10.05 – 10.25 Literature Review: Clinical Papers Children + discussion – TBA
10.25 – 10.50 Severe Manifestation of H1N1 – Jordi Rello, Critical Care Department, University Hospital Vall d’Hebron, Barcelona, Spain
10.50 – 11.05 Oral Presentation
Carrageenan Nasal Spray against Common Cold, a Double Blind Placebo Controlled Prospective Trial – Martin Ludwig, Medical University of Vienna, Department of Otolaryngology, Waehringer Gürtel, Vienna, Austria
11.05 – 11.35 Coffee Break

Session VI Antivirals and Therapeutics – Chair: Menno de Jong, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
11.35 – 12.00 Antivirals for Respiratory Viruses Overview – Menno de Jong, University of Amsterdam, The Netherlands
12.00 – 12.25 RNA Interference Strategies for Respiratory Virus Infection – John DeVincenzo, University of Tennessee, Memphis, Tennessee, USA
12.25 – 12.40 Oral Presentation
The Influenza Resistance Information Study (IRIS): Patterns and Predictors of Antiviral Drug Treatment – Drew Griffin Levy, Genentech, South San Francisco, California, USA
12.40 – 12.55 Oral Presentation
A Systematic Review on the Impact of Neuraminidase Inhibitor Antiviral use on Outcomes of Public Health Importance during the 2009/10 (Swine) Pandemic Influenza A/H1N1v – Stella Muthuri, University of Nottingham, United Kingdom
12.55 – 13.10 Oral Presentation
Clinical and Virological Response to Oseltamivir in Infants <1 year with Influenza
Barbara Rath, Charité University Medical Center, Berlin, Germany
13.10 – 13.25 Oral Presentation
Widespread Use of Neuraminidase Inhibitors in Japan, and Several Issues to Be Resolved – Norio Sugaya, Department of Pediatrics, Keiyu Hospital, Yokohama, Japan
13.25 Symposium Adjourns for the Day – free afternoon and evening

Day Four — Monday, 26 March 2012

Session VI Antivirals and Therapeutics – Chair: Menno de Jong, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (continued)
09.00 – 09.15 Oral Presentation
Macrolides and Anti-Inflammatory Agents in the Treatment of Avian Influenza (H5N1) – Ahmet Faik Oner, Yuzuncu Yil University, Van, Turkey
09.15 – 09.30 Oral Presentation
Pharmacokinetic-pharmacodynamic (PK-PD) determinants of oseltamivir efficacy using data from two Phase 2 inoculation studies – Craig Rayner, Roche Products Pty Ltd, South Melbourne, Australia
09.30 – 09.45 Oral Presentation
Screening Neuraminidase Inhibitor Susceptibility of Avian Influenza Isolates from SE Asia 2005-2009 identifies H5N1 I222 Mutants with Reduced Oseltamivir Sensitivity – Jennifer McKimm-Breschkin, CSIRO AAHL, Geelong, Australia
Session VII Vaccinology/Prevention – Chair: Nancy Cox, Director, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
09.45 – 10.10 New Vaccines for Respiratory Virus Infections – Adolfo Garcia-Sastre, Mt Sinai School of Medicine, New York, New York, USA

10.10 – 10.35 Update on Novel Influenza Vaccines – Rick Bright, Influenza Division, Biomedical Advanced Research and Development Authority (BARDA), Office of the Assistant Secretary for Preparedness and Response, U.S. Department of Health and Human Services, Washington, D.C.

10.35 – 10.50 Oral Presentation
Efficacy of Seasonal Influenza Vaccination in Children in Hong Kong: a Randomized Controlled Trial – Benjamin J. Cowling, School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong

10.50 – 11.05 Oral Presentation
Monoclonal Antibodies Cross-reacting with the Neuraminidase of Seasonal and 2009 Pandemic H1N1 Influenza Viruses – Hongquan Wan, Laboratory of Respiratory Viral Diseases, US Food and Drug Administration, Bethesda, Maryland, United States of America

11.05 – 11.35 Coffee Break

11.35 – 11.50 Oral Presentation
A Novel RSV Genetic Vaccine Candidate based on Chimpanzee Adenovirus and MVA Vectors is Safe and Highly Immunogenic in Rodents and Primates and fully Protects Cotton Rats from RSV Challenge – Alessandra Vitelli, Okairos Srl, Pomezia, Rome, Italy

11.50 – 12.05 Oral Presentation
Safety and Immunogenicity of a Recombinant RSV F Protein Nanoparticle Vaccine Manufactured in Insect Cells: a Phase I Dose and Formulation-finding Trial in Adults – Louis F. Fries, Novavax, Inc., Rockville, Maryland, USA

12.05 – 12.20 Oral Presentation
Immunogenicity and Safety of H1N1 Vaccination in Adults aged 19–40 years Vaccinated with Seasonal Influenza Vaccine 4 months Previously – Sumita Roy-Ghanta, GlaxoSmithKline Biologicals, King of Prussia, Pennsylvania, USA

12.20 – 12.35 Oral Presentation
Evidence of Virus Interference? Increased Risk of Non-influenza Respiratory Virus Infections Associated with Receipt of Inactivated Influenza Vaccine – Dr Benjamin J Cowling, School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong SAR

12.35 – 12.50 Oral Presentation
A Novel Human Respiratory Sycytial Virus Vaccine Based on the Extracellular Doman of the Small Hydrophobic Protein – Xavier Saelens, VIB and Ghent University, Ghent, Belgium

12.50 – 13.20 Closing Panel: Selim Badur, Nancy Cox, Ab Osterhaus, Arnold Monto, Fred Hayden